Application of NVP (N-vinylpyrrolidone)

By improving the solubility, it has been studied that it has a rapid dissolution rate so that it can be released within 30 minutes. In vitro studies have shown that this limits their bioavailability. The dissolution rate of azithromycin is increased. Due to its poor water solubility, clinical applications are limited. One of the potential treatments of Plukast is the preparation of a suspension of miconazole and itraconazole with an average particle size of about 210 nm by the media grinding method. Dry and combine to prepare an azithromycin suspension with an average particle size of about 200nm. These have low water solubility and they use sodium lauryl sulfate and cellulose ether or poloxamer as stabilizers. Wang and his colleagues prepared Pranlukast suspension 318.2 ± 7.3nm by a high-pressure homogenization method. They used poloxamer 407 as a stabilizer and polyethylene glycol 200 as a surfactant.

Suspension to enhance the oral bioavailability of Olmesartan medoxomil. The suspension exhibited more significant dissolution than the commercially available and traditional suspensions. 70% of the lyophilized suspension formula dissolves within 5 minutes and dissolves within 15 minutes. The traditional one only dissolves 12% after 5 minutes, and 92% after 60 minutes. The suspension is freeze-dried to obtain solid particles. The bioavailability of these suspensions in vivo is 4.38 times higher than that of the original crystals.

Compared to the crude suspension, the solubility of miconazole suspension sprayed or lyophilized was twice as high at 10 and 20 minutes. The freeze-dried itraconazole suspension did not show a faster solubility than the freeze-dried crude suspension, but the itraconazole suspension formed by spray drying had a faster solubility, in less than 10 minutes , Can dissolve 60%, and this requires 30-45 minutes in a crude suspension. Simvastatin lowers blood lipids, and its oral bioavailability is less than 5%. Athul uses PVP K30 as a stabilizer to prepare a suspension with a particle size in the range of 240-244 nm by a high-pressure homogenization method. The homogenized suspension is freeze-dried, and its large release within 1 hour 98.73%, and at the same time, its API only has a large release of 45.90%.